| 1986 #1 hit for Patti LaBelle and Michael McDonald |
| Throne material on "Game of Thrones" |
| Supporting |
| Gotham inits. |
| Lovelace of early computing |
| ___ Lady of Guadalupe |
| Popular depilatory |
| Editing device suggested by 17-, 23-, 33- and 46-Across? |
| Often-frazzled comics character |
| Crossed |
| Rank below adm. |
| Bequeaths |
| Michelle Obama or Jill Biden, informally |
| Seating section |
| Start of the Depression [1987, 2004] |
| Request accompanying puppy dog eyes, maybe |
| What the N.B.A.'s SuperSonics became in 2008 |
| ___-Signal |
| Mystery writer? |
| ___ Lankan |
| Type of rice |
| ___ alphabet |
| Busy body? |
| Mac-versus-PC and others |
| Popular New Orleans dessert |
| Like some glasses |
| Lead-in to sax |
| Highly respected |
| Dream big |
| "Full Metal Jacket" setting, in brief |
| Help button |
| Place to hide in hide-and-seek |
| Works of Picasso y Goya |
| Surprise for a statistician |
| Some celebrity sporting events |
| ___ vera |
| Hwy. |
| "Funky Cold Medina" rapper |
| Rampage |
| It was cool in the '90s |
| In the bargain bin, say |
| Dwindle |
| Tennis feat |
| Birthplace of Homo sapiens |
| Nikon D3500, e.g. |
| So-called "Godfather of the Teamsters" |
| Certain lap dog, informally |
| Be bedridden, say |
| Classic song that starts "I was working in the lab late one night" [2003, 1970] |
| Search blindly |
| Small wind instrument |
| Allende who wrote "City of the Beasts" |
| Big Apple subway inits. |
| Goes back to square one |
| Opposite of norte |
| Moral code |
| Email addenda, for short |
| Alma mater for Martha Stewart and Joan Rivers |
| Vegas hotel and casino that is the longtime host of the World Series of Poker |
| Gamblers' calculations |
| Hurdles for many honor students, in brief |
| Something most babies do at around six months |
| The Rams scored none of these in the '19 Super Bowl, and the Chiefs none in '21 |
| Donkey Kong, for one |
| Ex-seniors |
| Line at the top or bottom of a website [1997, 2019] |
| Commuter's headache [1998, 2000] |
| Sickly-looking |
| Strives (to) |
| Mattress size |
| Viking beverage |
| Big break |
| Help up a slope |
| 58-Across between Lou and Bess |